Numerical Methods for the Life Scientist
Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.
| Autor: | Prinz, Heino |
|---|---|
| ISBN: | 9783642208195 |
| Sprache: | Englisch |
| Seitenzahl: | 149 |
| Produktart: | Gebunden |
| Verlag: | Springer Berlin |
| Veröffentlicht: | 06.08.2011 |
| Untertitel: | Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB |
| Schlagworte: | Enzyme kinetics advanced textbook binding kinetics biochemistry dose-response curves numerical solutions to reaction schemes |