Matrix Proteases in Health and Disease
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
| ISBN: | 9783527329915 |
|---|---|
| Sprache: | Englisch |
| Produktart: | Gebunden |
| Herausgeber: | Behrendt, Niels |
| Verlag: | Wiley-VCH |
| Veröffentlicht: | 06.06.2012 |
| Schlagworte: | Biowissenschaften Cell & Molecular Biology Chemie Drug Discovery & Development Enzyme Enzymes & Receptors Enzyme u. Rezeptoren Life Sciences Molekularbiologie Proteasen Wirkstoffforschung u. -entwicklung Zell- u. Molekularbiologie chemistry |
Niels Behrendt is a research group leader at the Finsen Laboratory at the Rigshospitalet (Copenhagen University Hospital), Denmark. He obtained his Ph.D. in 1989 and his D.Sc. degree from Copenhagen University in 2004. The main focus of his work is in protease-dependent tissue remodeling, the interplay of these processes with other cellular functions and their role in cancer invasion.