Leucine-Rich Repeat Kinase 2 (LRRK2)
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
ISBN: | 9783319499673 |
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Sprache: | Englisch |
Seitenzahl: | 271 |
Produktart: | Gebunden |
Herausgeber: | Rideout, Hardy J. |
Verlag: | Springer International Publishing |
Veröffentlicht: | 04.04.2017 |
Schlagworte: | GTPase Parkinson's Disease kinase neurodegeneration signaling |