Drug Metabolism and Transport
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
| ISBN: | 9781617374944 |
|---|---|
| Sprache: | Englisch |
| Seitenzahl: | 388 |
| Produktart: | Kartoniert / Broschiert |
| Herausgeber: | Lash, Lawrence H. |
| Verlag: | Humana Press |
| Veröffentlicht: | 09.11.2010 |
| Untertitel: | Molecular Methods and Mechanisms |
| Schlagworte: | cytochrome P450 detoxification drug drug resistance metabolism research resistance toxicity toxicology xenobiotic |